Originalni "Scooby-Doo, gdje si!" Serija (1969-1970):
* Scooby-Doo: Don Messick
* Shaggy Rogers: Casey Kasem
* Fred Jones: Frank Welker
* Daphne Blake: Stefanianna Christopherson (1. sezona), Heather North (2. sezona)
* Velma Dinkley: Nicole Jaffe
Kasnije serije i filmovi:
* Scooby-Doo (film iz 2002.):
* Scooby-Doo: Neil Fanning
* Shaggy Rogers: Matthew Lillard
* Fred Jones: Freddie Prinze Jr.
* Daphne Blake: Sarah Michelle Gellar
* Velma Dinkley: Linda Cardellini
* Scooby-Doo 2:Monsters Unleashed (film iz 2004.):
* Scooby-Doo: Neil Fanning
* Shaggy Rogers: Matthew Lillard
* Fred Jones: Freddie Prinze Jr.
* Daphne Blake: Sarah Michelle Gellar
* Velma Dinkley: Linda Cardellini
* Scooby-Doo! Mystery Incorporated (2010.-2013.):
* Scooby-Doo: Frank Welker
* Shaggy Rogers: Matthew Lillard
* Fred Jones: Adam Pally
* Daphne Blake: Grey DeLisle
* Velma Dinkley: Mindy Cohn
* Scooby-Doo i pogodi tko? (2019.-danas):
* Scooby-Doo: Frank Welker
* Shaggy Rogers: Matthew Lillard
* Fred Jones: Frank Welker
* Daphne Blake: Grey DeLisle
* Velma Dinkley: Mindy Cohn
Napomena: Ovo je samo izbor glavnih glumaca i glumica. Mnogi drugi talentirani glumci i glumice dali su glasove likovima u raznim Scooby-Doo projektima tijekom godina.